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pentobarbital will enhance the level or outcome of ivosidenib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of ivosidenib with potent CYP3A4 inducers decreased ivosidenib plasma concentrations.pentobarbital will lessen the extent or influence of darunavir by affecting hepatic/intest